Optogenetic Control of Body Movements via Flexible Vertical Light-Emitting Diodes on Brain Surface

Title
Optogenetic Control of Body Movements via Flexible Vertical Light-Emitting Diodes on Brain Surface
Authors
김정진이승현신정호이한솔강일석곽기욱김대식김대수이건재
Keywords
Light-emitting diode; Anisotropic conductive film; Optogenetics; Motor cortex; Flexible optoelectronics
Issue Date
2018-02
Publisher
Nano energy
Citation
VOL 44-455
Abstract
The microstimulation of specific neural populations of the brain is one of the facile and reliable methods used in neuroscience for deduction of functional movement, complex behavior and even long-range connectivity. Recent advanced biomedical tools now employ flexible optoelectronic devices combined with optogenetic mouse models to induce high spatiotemporal modulation of specific brain activity. However, most current applications are limited to activation of small functional regions using blue-light driven channelrhodopsin. In this report, we introduce flexible AlGaInP vertical light-emitting diodes (VLEDs) for perturbation of specific functional areas of mouse cortex. Micro-scaled LEDs effectively compress the conductive balls dispersed in anisotropic conductive film (ACF) resulting red light emissions with high optical power density, capable of stimulating motor neurons deep below layer III from the brain surface. Selective operation of pulsed red light from f-VLEDs induces mouse body movements and synchronized electromyogram (EMG) signals. The expression of chrimson, red-shifted channelrhodopsin, enables red-light excitation of targeted functional area of motor cortex. This demonstration opens new opportunities for entire cortical mapping, to explore the connectivity between undefined motor areas in the mouse brain.
URI
http://pubs.kist.re.kr/handle/201004/67228
ISSN
2211-2855
Appears in Collections:
KIST Publication > Article
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