Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
- Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
- 김종현; Kogo Takamiya; Ronald S Petralia; Rita Sattler; Sandy Yu; Weiguo Zhou; Robert Kalb; Robert Wenthold; Richard Huganir
- Issue Date
- Nature neuroscience
- VOL 8, NO 8-987
- The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
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