Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Title
Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1
Authors
김종현Kogo TakamiyaRonald S PetraliaRita SattlerSandy YuWeiguo ZhouRobert KalbRobert WentholdRichard Huganir
Issue Date
2005-08
Publisher
Nature neuroscience
Citation
VOL 8, NO 8-987
Abstract
The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.
URI
http://pubs.kist.re.kr/handle/201004/67234
ISSN
1097-6256
Appears in Collections:
KIST Publication > Article
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