A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation

Title
A Specific Groove Pattern Can Effectively Induce Osteoblast Differentiation
Authors
김상훈전호정쭝 히에우 쩐김창수김진희김보경박영석김홍균김상집심지현신현무김광훈백용주이기준김해영윤태진김윤상김항래
Issue Date
2017-11
Publisher
Advanced functional materials
Citation
VOL 27, NO 44-1703569-12
Abstract
Little is known about the principles of surface structure design for orthopedic and dental implants. To find topographical groove patterns that could enhance osteoblast differentiation according to cell type, groove patterns are fabricated with ridges (0.35− 7 µ m) and grooves (0.65− 6 µ m) of various widths and explored their mechanisms in improving osteoblast differentiation. This study finds that a groove pattern enhancing osteoblast differentiation is associated with the ability of the cell to extend its length and that it is able to overcome the inhibition of osteoblast differentiation that takes place under inflammatory conditions. The groove pattern suppresses the generation of reactive oxygen species, a reaction that is increased in inflammatory conditions. It also modulates the expression of osteogenic factors according to differentiation time. Importantly, specific groove patterns AZ-2 and AZ-4, with ridge width of 2 µ m and groove width of 2 or 4 µ m, respectively, effectively promote bone regeneration in critical-sized calvarial defects without additional factors. This knowledge of groove patterns can be applied to the development of orthopedic and dental devices.
URI
http://pubs.kist.re.kr/handle/201004/67275
ISSN
1616-301X
Appears in Collections:
KIST Publication > Article
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