Switching On Depression and Potentiation in the Cerebellum

Title
Switching On Depression and Potentiation in the Cerebellum
Authors
게이코 야마모토김태곤Andrew R. GallimoreErik De Schutter
Issue Date
2018-01
Publisher
Cell Reports
Citation
VOL 22, NO 3-733
Abstract
Long-term depression (LTD) and long-term potentiation (LTP) in the cerebellum are important for motor learning. However, the signaling mechanisms controlling whether LTD or LTP is induced in response to synaptic stimulation remain obscure. Using a unified model of LTD and LTP at the cerebellar parallel fiber-Purkinje cell (PF-PC) synapse, we delineate the coordinated pre- and postsynaptic signaling that determines the direction of plasticity. We show that LTP is the default response to PF stimulation above a well-defined frequency threshold. However, if the calcium signal surpasses the threshold for CaMKII activation, then an ultrasensitive ‘‘on switch’’ activates an extracellular signal-regulated kinase (ERK)-based positive feedback loop that triggers LTD instead. This postsynaptic feedback loop is sustained by another, trans-synaptic, feedback loop that maintains nitric oxide production throughout LTD induction. When full depression is achieved, an automatic ‘‘off switch’’ inactivates the feedback loops, returning the network to its basal state and demarcating the end of the early phase of LTD.
URI
http://pubs.kist.re.kr/handle/201004/67280
ISSN
2211-1247
Appears in Collections:
KIST Publication > Article
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