Implantation of a Matrigel-loaded agarose scaffold promotes functional regeneration of axons after spinal cord injury in rat

Title
Implantation of a Matrigel-loaded agarose scaffold promotes functional regeneration of axons after spinal cord injury in rat
Authors
윤인찬한성민이지윤허은영권일근윤태영
Keywords
spinal cord; ultrasound stimulation; regeneration; corticospinal tract; agarose scaffold; functional connectivity
Issue Date
2018-02
Publisher
Biochemical and biophysical research communications
Citation
VOL 496, NO 3-791
Abstract
An agarose scaffold can be useful for supporting and guiding injured axons after spinal cord injury (SCI), but the electrophysiological signal of regenerated axon in scaffolds has not yet been determined. The current study investigated whether a Matrigel-loaded agarose scaffold would enhance the regeneration of axons after SCI. Moreover, the functional connectivity of regenerated axons within the channels of the scaffold was evaluated by directly recording motor evoked potentials. Our data showed that the agarose scaffold containing Matrigel can support and enhance linearly organized axon regeneration after SCI. Additionally, motor evoked potentials were successfully recorded from regenerated axons. These results demonstrate that an agarose scaffold loaded with Matrigel could promote the regeneration of axons and guide the reconnection of functional axons after SCI.
URI
http://pubs.kist.re.kr/handle/201004/67293
ISSN
0006-291X
Appears in Collections:
KIST Publication > Article
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