Identification of Tumor Initiating Cells with a Small-Molecule Fluorescen tProbe by Using Vimentin as a Biomarker

Title
Identification of Tumor Initiating Cells with a Small-Molecule Fluorescen tProbe by Using Vimentin as a Biomarker
Authors
이준석장세영이용안김종진이정열Jia Hui Jane LeeSrikanta Sahu권화영박성진Zhenxun WangWai Leong TamBing Lim강남영장영태
Keywords
antitumor agent; biomarker; cancer; fluorescent probe
Issue Date
2018-03
Publisher
Angewandte Chemie international edition
Citation
VOL 57, NO 11-2854
Abstract
Tumor initiating cells (TICs) have been implicated in clinical relapse and metastasis of a variety of epithelial cancers, including lung cancer. While efforts toward the development of specific probes for TIC detection and targeting are ongoing, a universal TIC probe has yet to be developed. We report the first TIC-specific fluorescent chemical probe, TiY, with identification of the molecular target as vimentin, a marker for epithelial-to-mesenchymal transition (EMT). TiY selectively stains TICs over differentiated tumor cells or normal cells, and facilitates the visualization and enrichment of functionally active TICs from patient tumors. At high concentration, TiY also shows anti-TIC activity with low toxicity to non-TICs. With the unexplored target vimentin, TiY shows potential as a first universal probe for TIC detection in different cancers.
URI
http://pubs.kist.re.kr/handle/201004/67360
ISSN
1433-7851
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KIST Publication > Article
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