A New Method for the Cleavage of Nitrobenzyl Amides and Ethers

Title
A New Method for the Cleavage of Nitrobenzyl Amides and Ethers
Authors
한서정Gabriel Fernando de MeloBrian M. Stoltz
Issue Date
2014-11
Publisher
Tetrahedron letters
Citation
VOL 55, NO 47-6469
Abstract
A mild and efficient o- and p-nitrobenzyl cleavage protocol was developed. o- and p-nitrobenzyl groups were easily removed from a variety of substrates using 20% aqueous NaOH in methanol at 75 degrees C, presumably via oxidation at the benzylic position by oxygen dissolved in the solution. These easily introducible and removable nitrobenzyl groups can serve as valuable protecting groups for the synthesis of multifunctional, complex molecules.
URI
http://pubs.kist.re.kr/handle/201004/67367
ISSN
0040-4039
Appears in Collections:
KIST Publication > Article
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