Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile To Form Light-ResponsiveVesicles

Title
Mono-allyloxylated Cucurbit[7]uril Acts as an Unconventional Amphiphile To Form Light-ResponsiveVesicles
Authors
이준석박경민백강균고용호Annadka ShrinidhiJames Murray장원혁김기현유제중김성환김기문
Keywords
amphiphiles; cucurbiturils; drug delivery
Issue Date
2018-03
Publisher
Angewandte Chemie international edition
Citation
VOL 57, NO 12-3136
Abstract
Serendipitously, mono-allyloxylated cucurbit[7]uril (AO1CB[7]) was discovered to act as an unconventional amphiphile which self-assembles into light-responsive vesicles (AO1CB[7]VC) in water. Although the mono-allyloxy group, directly tethered on the periphery of CB[7], is much shorter (C4) than the hydrophobic tails of conventional amphiphiles, it played an important role in vesicle formation. Light-activated transformation of the allyloxy group by conjugation with glutathione was exploited as a remote tool to disrupt the vesicle. The vesicle showed on-demand release of cargo upon irradiation by a laser, after they were internalized into cancer cells. This result demonstrated the potential of AO1CB[7]VC as a new type of light-responsive intracellular delivery vehicle for the release of therapeutic cargo, within cells, on demand.
URI
http://pubs.kist.re.kr/handle/201004/67392
ISSN
1433-7851
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE