Fucoxanthin bioavailability from fucoxanthin-fortified milk: In vivo and in vitro study

Title
Fucoxanthin bioavailability from fucoxanthin-fortified milk: In vivo and in vitro study
Authors
판철호김상민목일균이재권김정화
Keywords
bioavailability; bioaccessibility; fucoxanthin; skimmed milk; Phaeodactylum tricornutum
Issue Date
2018-08
Publisher
Food chemistry
Citation
VOL 258-86
Abstract
Our previous study reported the improved stability of fucoxanthin (FX) fortified in whole milk (WM) and skimmed milk (SM). In this study, in vivo and in vitro FX bioavailability were investigated using FX-fortified milk (FX-SM and FX-WM) and microalga Phaeodactylum tricornutum biomass (Pt-powder). Organ tissue accumulation of FX and its metabolites (FXOH: fucoxanthinol, AXA: amarouciaxanthin A) after repeated oral administration was in the following order: FX-SM  >  FX-WM  Pt-powder. In vivo pharmacokinetic study with a single oral administration also demonstrated that the absorption of FXOH and AXA was the highest for FX-SM. To reinforce the in vivo results, in vitro-simulated digestion and Caco-2 cell uptake assays were performed, which revealed that FX-SM showed the highest FX bioaccessibility (release from food matrices) and cellular uptake efficiency of FX and FXOH. In conclusion, skimmed milk was validated as an excellent food matrix for FX application in terms of stability and bioavailability.
URI
http://pubs.kist.re.kr/handle/201004/67427
ISSN
0308-8146
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KIST Publication > Article
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