Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids
- Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids
- 문주연; Megumi Tsuchiya; Kanako Miyabayashi; Hidesato Ogawa; Yuichi Shima; Lixiang Wang; Ryuichiro Sato; Takeshi Yamazaki; Mikita Suyama; Masatoshi Nomura; Yasuyuki Ohkawa; Ken-ichirou Morohashi; 최만호; Takashi Baba; Hiroyuki Otake; Miki Inoue; Tetsuya Sato; Yasuhiro Ishihara
- cholesterol; steroidogenesis; Ad4BP/SF-1
- Issue Date
- Communications biology
- VOL 1, NO 18-9
- Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition,
many types of cells are equipped with cell-specific metabolic pathways. To properly perform
their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely
unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/
SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes.
Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that
Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis
and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level.
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