Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids

Title
Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids
Authors
문주연Megumi TsuchiyaKanako MiyabayashiHidesato OgawaYuichi ShimaLixiang WangRyuichiro SatoTakeshi YamazakiMikita SuyamaMasatoshi NomuraYasuyuki OhkawaKen-ichirou Morohashi최만호Takashi BabaHiroyuki OtakeMiki InoueTetsuya SatoYasuhiro Ishihara
Keywords
cholesterol; steroidogenesis; Ad4BP/SF-1
Issue Date
2018-04
Publisher
Communications biology
Citation
VOL 1, NO 18-9
Abstract
Housekeeping metabolic pathways such as glycolysis are active in all cell types. In addition, many types of cells are equipped with cell-specific metabolic pathways. To properly perform their functions, housekeeping and cell-specific metabolic pathways must function cooperatively. However, the regulatory mechanisms that couple metabolic pathways remain largely unknown. Recently, we showed that the steroidogenic cell-specific nuclear receptor Ad4BP/ SF-1, which regulates steroidogenic genes, also regulates housekeeping glycolytic genes. Here, we identify cholesterogenic genes as the targets of Ad4BP/SF-1. Further, we reveal that Ad4BP/SF-1 regulates Hummr, a candidate mediator of cholesterol transport from endoplasmic reticula to mitochondria. Given that cholesterol is the starting material for steroidogenesis and is synthesized from acetyl-CoA, which partly originates from glucose, our results suggest that multiple biological processes involved in synthesizing steroid hormones are governed by Ad4BP/SF-1. To our knowledge, this study provides the first example where housekeeping and cell-specific metabolism are coordinated at the transcriptional level. 1
URI
http://pubs.kist.re.kr/handle/201004/67428
ISSN
2399-3462
Appears in Collections:
KIST Publication > Article
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