Enhancing the antimicrobial effect of genistein by biotransformation in microbial system

Title
Enhancing the antimicrobial effect of genistein by biotransformation in microbial system
Authors
박진수HaeRi ChoiKyu-Min KimMinSun KimKwang-Wook KoChang-Gu HyunJoong Woo AhnJoo-Hyun SeoSeung-Young Kim
Issue Date
2018-07
Publisher
Journal of industrial and engineering chemistry
Citation
VOL 63-261
Abstract
In this study, we report Bio-renovation, which is a method to biologically derivatize natural compounds to make drug candidate library. In this method, microorganisms produce various derivatives of natural compounds, thereby converting natural compounds into novel bioactive candidates. Five derivatives of genistein were synthesized by Bio-renovation using Bacillus amyloliquefaciens KCTC 13588. Among the genistein derivatives, 40-O-isopropyl genistein showed antimicrobial activity against eight strains including methicillin resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) with MIC and MBC values of 8– 128 mg/ml. We could find that 40-O-isopropyl genistein has higher antimicrobial activity than genistein to gram-positive bacteria.
URI
http://pubs.kist.re.kr/handle/201004/67430
ISSN
1226-086X
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KIST Publication > Article
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