Nitrite ion mitigates the formation of N-nitrosodimethylamine (NDMA) during chloramination of ranitidine

Title
Nitrite ion mitigates the formation of N-nitrosodimethylamine (NDMA) during chloramination of ranitidine
Authors
박현미홍석원민기Kangwoo ChoChangha Lee
Keywords
N-nitrosodimethylamine; Ranitidine; Nitrite ion; Chloramination; Kinetics; Reaction pathway
Issue Date
2018-08
Publisher
The Science of the total environment
Citation
VOL 633-359
Abstract
, the ultimate molar yield of NDMA after 6 h of reaction was primarily influenced by [DO] and pH, while marginally affected by initial [RNT] and [NH2Cl]. A kinetic model, prepared in accordance with the reaction sequence of NDMA formation, suggested that the rate determining step was accelerated with increasing [NH2Cl]0, [DO], and pH. A Kinetic study together with ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometer (UPLC-Q-TOF MS) and gas chromatography (GC)/TOF MS analyses in parallel demonstrated that the nitrite ion inhibited the nucleophilic substitution of the terminal amine on NH2Cl, and reduced the pseudo-steady state concentration of N-peroxyl radicals, significantly decreasing the ultimate yields of NDMA.; Ranitidine (RNT) has been an important tertiary amine precursor of N-nitrosodimethylamine (NDMA) in chlorine-based water treatment, due to reaction with monochloramine (NH2Cl) with exceptionally high molar yields up to 90%. This study examined the effects of nitrite ions (NO2− ) on the kinetics of NDMA formation during the chloramination of RNT under variable concentrations of dissolved oxygen (DO, 0.7– 7.5 mg/L), RNT (5– 30 μM), NH2Cl (5– 20 mM), NO2− or NO3− (0– 2 mM) and pH (5.6– 8.6). In the absence of the NO2&#8722
URI
http://pubs.kist.re.kr/handle/201004/67454
ISSN
0048-9697
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