The present and the future of motif-mediated protein-protein interactions

Title
The present and the future of motif-mediated protein-protein interactions
Authors
서문형Philip M. Kim
Keywords
Protein-protein interaction; Peptide motif; Drug development
Issue Date
2018-06
Publisher
Current opinion in structural biology
Citation
VOL 50-170
Abstract
Protein– protein interactions (PPIs) are essential to governing virtually all cellular processes. Of particular importance are the versatile motif-mediated interactions (MMIs), which are thus far underrepresented in available interaction data. This is largely due to technical difficulties inherent in the properties of MMIs, but due to the increasing recognition of the vital roles of MMIs in biology, several systematic approaches have recently been developed to detect novel MMIs. Consequently, rapidly growing numbers of motifs are being identified and pursued further for therapeutic applications. In this review, we discuss the current understanding on the diverse functions and disease-relevance of MMIs, the key methodologies for detection of MMIs, and the potential of MMIs for drug development.
URI
http://pubs.kist.re.kr/handle/201004/67645
ISSN
0959-440X
Appears in Collections:
KIST Publication > ETC
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