Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes

Title
Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes
Authors
정용채김영오Sieun ChaeDahee KimKyung-jin LeeDasol LeeSang Dal RheeKwang Rok KimJeong-O LeeSunjoo AhnByumseok Koh
Issue Date
2018-06
Publisher
ACS omega
Citation
VOL 3, NO 6-5945
Abstract
The topoisomerase I inhibitors SN-38 and camptothecin (CPT) have shown potent anticancer activity, but water insolubility and metabolic instability limits their clinical application. Utilizing carbon nanotubes as a protective shell for water-insoluble SN-38 and CPT while maintaining compatibility with aqueous media via a carboxylic acid-functionalized surface can thus be a strategy to overcome this limitation. Through hydrophobic– hydrophobic interactions, SN-38 and CPT were successfully encapsulated in carboxylic acid functionalized single-walled carbon nanotubes and dispersed in water. The resulting cell proliferation inhibition and drug distribution profile inside the cells suggest that these drug-encapsulated carbon nanotubes can serve as a promising delivery strategy for water-insoluble anticancer drugs.
URI
http://pubs.kist.re.kr/handle/201004/67685
ISSN
2470-1343
Appears in Collections:
KIST Publication > Article
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