Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae

Title
Cytotoxic Drimane Sesquiterpenoids Isolated from Perenniporia maackiae
Authors
권학철권재영이준서영혜Hyaemin LeeJieun YunYuanqiang GuoJong Soon KangJae-Jin KimDongho Lee
Issue Date
2018-06
Publisher
Journal of natural products
Citation
VOL 81, NO 6-1450
Abstract
A chemical investigation of a basidiomycetes fungus, Perenniporia maackiae, led to the discovery of 12 drimane sesquiterpenoids, including seven new constituents (1-7). The elucidation of the structures was performed via interpreting extensive spectroscopic methods, including ECD calculations. Among all isolated compounds, 1, 2, and 6 exhibited cytotoxicity toward six carcinoma cells, including ACHN, HCT-15, MDA-MB-231, NCI-H23, NUGC-3, and PC-3 cells, with half-maximal inhibition of cell proliferation values of 1.2-6.0 mu M.
URI
http://pubs.kist.re.kr/handle/201004/67775
ISSN
0163-3864
Appears in Collections:
KIST Publication > Article
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