Ketamine Inhibits Ultrasound Stimulation-Induced Neuromodulation by Blocking Cortical Neuron Activity

Title
Ketamine Inhibits Ultrasound Stimulation-Induced Neuromodulation by Blocking Cortical Neuron Activity
Authors
신현준윤인찬김형민한성민김민경
Keywords
neuromodulation; cortical neuron; ketamine; ultrasound stimulation
Issue Date
2018-03
Publisher
ULTRASOUND IN MEDICINE AND BIOLOGY
Citation
VOL 44, NO 3-646
Abstract
Ultrasound (US) can be used to noninvasively stimulate brain activity. However, reproducible motor responses evoked by US are only elicited when the animal is in a light state of anesthesia. The present study investigated the effects of ketamine on US-induced motor responses and cortical neuronal activity. US was applied to the motor cortex of mice, and motor responses were evaluated based on robustness scores. Cortical neuronal activity was observed by fluorescence calcium imaging. US-induced motor responses were inhibited more than 20  min after ketamine injection, and US-triggered Ca2+ transients in cortical neurons were effectively blocked by ketamine. Our results indicate that ketamine suppresses US-triggered Ca2+ transients in cortical neurons and, therefore, inhibits US-induced motor responses in a deep anesthetic state.
URI
http://pubs.kist.re.kr/handle/201004/67845
ISSN
0301-5629
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE