Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability

Title
Deubiquitinase USP35 as a novel mitotic regulator via maintenance of Aurora B stability
Authors
송은주박진영
Keywords
USP35; deubiquitinating enzyme; mitosis
Issue Date
2018-06
Publisher
BMB REPORTS
Citation
VOL 51, NO 6-262
Abstract
Aurora B is an important kinase involved in dynamic cellular events in mitosis. Aurora B activity is controlled by several post-translational modifications (PTMs). Among them, E3 ubiquitin ligase-mediated ubiquitination plays crucial roles in controlling the relocation and degradation of Aurora B. Aurora B, ubiquitinated by different E3 ligases, moves to the exact site for its mitotic function during metaphase-anaphase transition and is then degraded for cell cycle progression at the end of mitosis. However, how the stability of Aurora B is maintained until its degradation has been poorly understood. Recently, we have found that USP35 acts as a deubiquitinating enzyme (DUB) for Aurora B and affects its stability during cell division, thus being involved in the regulation of mitosis. In this review, we discuss the USP35-mediated deubiquitination of Aurora B and the regulation of mitotic progression by USP35.
URI
http://pubs.kist.re.kr/handle/201004/67873
ISSN
1976-6696
Appears in Collections:
KIST Publication > Article
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