Revisiting of Pd nanoparticles in cancer treatment: all-round excellence of porous Pd nanoplates in gene-thermo combinational therapy

Title
Revisiting of Pd nanoparticles in cancer treatment: all-round excellence of porous Pd nanoplates in gene-thermo combinational therapy
Authors
김영관김영진강성훈신우준강경리최명호민달희장홍제
Keywords
팔라듐; 나노입자; 항암치료
Issue Date
2018-04
Publisher
ACS Applied Materials & Interfaces
Citation
VOL 10, NO 16-13828
Abstract
Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd). According to our analytical results, porous Pd nanoplates exhibited exceptional all-round excellence in photothermal conversion, therapeutic gene loading/releasing, cytotoxicity, and in vitro combination cancer treatment. We believe that this discovery broadens the potential applications of metal nanomaterials, with an emphasis on more efficient biomedical applications in limited conventional fields.
URI
http://pubs.kist.re.kr/handle/201004/67874
ISSN
1944-8244
Appears in Collections:
KIST Publication > Article
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