Differential representation of landmark and self-motion information along the CA1 radial axis: self-motion generated place fields shift toward landmarks during septal inactivation

Title
Differential representation of landmark and self-motion information along the CA1 radial axis: self-motion generated place fields shift toward landmarks during septal inactivation
Authors
세바스쳔 로열모하마드 파타히파나즈 샤리프재이예 트리스탕
Issue Date
2018-07
Publisher
Journal of neuroscience
Citation
VOL 38, NO 30-6778
Abstract
Spatial location in the environment can be defined in relation to specific landmarks or in relation to the global context, and is estimated from both the sensing of landmarks and the inner sense of cumulated locomotion referred to as path-integration. The respective contribution of landmark and path-integration to place cell activity in the hippocampus is still unclear and complicated by the fact that the two mechanisms usually overlap. To bias spatial mechanisms towards landmark or path-integration, we use a treadmill equipped with a long belt on which male mice run sequentially through a zone enriched and a zone impoverished in visual-tactile cues. We show that inactivation of the medial septum (MS), which is known to disrupt the periodic activity of grid cells, impairs mice ability to anticipate the delivery of a reward in the cue-impoverished zone and transiently alter the spatial configuration of place fields in the cue-impoverished zone selectively: following MS inactivation, place fields in the cue-impoverished zone progressively shift backward and stabilize near the cues, resulting in the contraction of the spatial representation around cues; following MS recovery, the initial spatial representation is progressively restored. Furthermore, we found that place fields in the cue-rich and cue-impoverished zones are preferentially generated by cells from the deep and superficial sublayers of CA1, respectively. These findings demonstrate with mechanistic insights the contribution of MS to the spread of spatial representations in cue-impoverished areas, and indicate a segregation of landmark-based and path-integration-assisted spatial mechanisms into deep and superficial CA1, respectively.
URI
http://pubs.kist.re.kr/handle/201004/67877
ISSN
0270-6474
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