Fluorescent Molecular Rotors for Viscosity Sensors
- Fluorescent Molecular Rotors for Viscosity Sensors
- 김세훈; 허정윤; 서영훈; 이승철; 우희철; 이지안; 이창렬; 권오필
- Issue Date
- Chemistry : a European journal
- VOL 24, NO 52-13718
- Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent p-conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push– pull type p-conjugated chromophores, meso-phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity-responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity-contrast trade-off) and their biological and microfluidic applications are also discussed.
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- KIST Publication > ETC
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