Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities

Title
Cytotoxic and anticancer properties of new ruthenium polypyridyl complexes with different lipophilicities
Authors
김상헌박민희배인영Anjong Florence TikumYu Jeong JeonJu Hyun LeeHye Jin LeeJinheung Kim
Issue Date
2018-03
Publisher
Journal of inorganic biochemistry
Citation
VOL 180-210
Abstract
Three ruthenium complexes containing a bidentate piq ligand, [(piq)Ru(bpy)(2)](2+) (1), [(piq)Ru(phen)(2)](2+) (2), and [(piq)Ru(DIP)(2)](2+). (3) (piq = phenylisoquinolinate, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, DIP = 4,7-dipheny1-1,10-phenanthroline), were prepared. The DNA binding properties of complexes 1-3 to double-stranded DNA were studied. The binding of 1-3 to calf-thymus DNA (ct-DNA) yielded lower emission intensities than those observed with the corresponding Ru complexes alone. To explore potential interactions of complexes 1-3 with lipid-rich organs in live cells, the emission properties of the Ru probes were studied with liposomes. The emission intensities of complexes 1-3 were enhanced to similar extents upon interaction with liposomes. The cytotoxic activities of the complexes against MDA-MB-231 and HUVECs were evaluated in vitro. The effects of complexes 1-3 on the survival of MDA-MB-231 cells were examined and compared with that of cisplatin. Complexes 2 and 3 were more cytotoxic to cancer cells than cis-platin. Complexes 1-3 showed cellular uptakes of 1.1, 10.6, and 76.6%, respectively, indicating that the greatest amount of complex 3 entered the cancer cells. Inhibition of cell migration by complexes 1-3 was also evaluated by the wound healing assay.
URI
http://pubs.kist.re.kr/handle/201004/68080
ISSN
0162-0134
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KIST Publication > Article
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