Reducing Effect of Saikosaponin A, an Active INgredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating
- Reducing Effect of Saikosaponin A, an Active INgredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating
- 권학철; 이정환; Paola Maccioni; Federica Fara; Gian Luigi Gessa; Mauro A.M. Carai; 진영원; Giancarlo Colombo
- 천연물; Natural Products; 과식; Overeating; 중독; addiction; 사이코사포닌; Saikosaponin; 시호; Bupleurum falcatum
- Issue Date
- Frontiers in Psychiatry
- VOL 9-349
- Recent lines of experimental evidence have indicated that saikosaponin A (SSA)-a bioactive ingredient of the medicinal plant, Bupleurum falcatum L.-potently and effectively reduced operant self-administration of chocolate and reinstatement of chocolate-seeking behavior in rats. The present study was designed to assess whether the protective properties of SSA on addictive-like, food-related behaviors generalize to a rat model of overeating of palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-h chow-feeding session was followed by a 1-h availability of highly palatable, calorie-rich Danish butter cookies or Oreo chocolate cookies. Even though fed, rats consumed large amounts of cookies; intake of calories from cookies (consumed in 1 h) was even larger than that of calories from chow (consumed in 3 h). SSA (0, 0.25, 0.5, and 1 mg/kg, i.p.) was administered 10min before cookie presentation. Treatment with SSA resulted in a dose-related decrease in intake of both butter and chocolate cookies. Administration of the cannabinoid CB1 receptor antagonist/inverse agonist, rimonabant (0, 0.3, 1, and 3 mg/kg, i.p.; tested as reference compound), produced a similar reduction in intake of butter cookies. These results (a) contribute to the set-up and validation of a rat model of overeating, characterized by the intake of large amounts of unnecessary calories and (b) provide an additional piece of evidence to the anorectic profile of SSA in rats.
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