Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents

Title
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Authors
오창현모하메드 사미르마그디 아마르
Keywords
MAPK; RAF 억제제; Anti-Cancer agents
Issue Date
2018-10
Publisher
European journal of medicinal chemistry
Citation
VOL 158-166
Abstract
Frequent oncogenic mutations have been identified in MAPK (mitogen-activated protein kinase) signaling pathway components. As a result, MAPK pathway is associated with human cancer initiation, in particular RAF (rapidly accelerated fibrosarcoma) component. The mutation in RAF component leads to auto-activation of MAPK signaling pathway, stimulating the uncontrolled cell growth and proliferation. In last few years, diverse chemical scaffolds have been identified as RAF inhibitors. Most of these scaffolds show potent anti-cancer activity. The present review highlights the recent investigations of RAF inhibitors during the last five years.
URI
http://pubs.kist.re.kr/handle/201004/68102
ISSN
0223-5234
Appears in Collections:
KIST Publication > ETC
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