Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity

Title
Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity
Authors
안대로히엔 타이Fabienne Levi-Acobas염수영장구Marcel Hollenstein
Issue Date
2018-09
Publisher
Chemical communications
Citation
VOL 54, NO 68-9413
Abstract
We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.
URI
http://pubs.kist.re.kr/handle/201004/68195
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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