Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity
- Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity
- 안대로; 히엔 타이; Fabienne Levi-Acobas; 염수영; 장구; Marcel Hollenstein
- Issue Date
- Chemical communications
- VOL 54, NO 68-9413
- We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.
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