Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures
- Biodegradable sheath-core biphasic monofilament braided stent for bio-functional treatment of esophageal strictures
- 정윤기; 이유진; 한철민; Tarek Mosaid Ismail Bedair; 최슬기; 이영재; 박우람; 한동근; 손준식
- Issue Date
- Journal of industrial and engineering chemistry
- VOL 67-406
- In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24 N, while that of PDO stent was 5.64 N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid-dopamine conjugate and BaSO4/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.
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