Covalent immobilization of fibroblast-derived matrix on metallic stent for expeditious re-endothelialization

Title
Covalent immobilization of fibroblast-derived matrix on metallic stent for expeditious re-endothelialization
Authors
정윤기타렉베딜민일재박우람박방주한동근
Issue Date
2019-02
Publisher
Journal of industrial and engineering chemistry
Citation
VOL 70-393
Abstract
Here, we demonstrate a fibroblast-derived extracellular matrix (FDM) immobilized cobalt-chromium (Co– Cr) alloy surface to accelerate re-endothelialization. The surface characterization results showed that FDM molecules with their protein components such as collagen I, fibronectin, and laminin, were covalently grafted to Co– Cr surface. The in vitro cells experiments exhibited the superiority of the FDM-immobilized surface to capture and proliferate of endothelial progenitor and human umbilical cord vein endothelial cells than control Co– Cr alloy. These results suggested that the immobilization of FDM on the stent surface by this facile procedure could be an efficient and promising strategy to get expeditious re-endothelialization.
URI
http://pubs.kist.re.kr/handle/201004/68975
ISSN
1226-086X
Appears in Collections:
KIST Publication > Article
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