Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes

Title
Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes
Authors
이준석Linghui QianSijun PanJingyan GeLin LiShao Q Yao
Keywords
c-Jun N-terminal kinase; inhibitor
Issue Date
2019-01
Publisher
Chemical communications
Citation
VOL 55-1095
Abstract
c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed twophoton fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs.
URI
http://pubs.kist.re.kr/handle/201004/68980
ISSN
1359-7345
Appears in Collections:
KIST Publication > Article
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