Size control of cross-linked carboxy-functionalized polystyrene particles: Four orders of magnitude of dimensional versatility

Title
Size control of cross-linked carboxy-functionalized polystyrene particles: Four orders of magnitude of dimensional versatility
Authors
강진구Nina M. SekerakKristin M. HutchinsBinbin LuoPaul V. BraunQian ChenJeffrey S. Moore
Issue Date
2018-04
Publisher
European polymer journal
Citation
VOL 101-210
Abstract
Synthesis of functionalized organic particles is an expanding area of exploration due to versatile potential applications including imaging agents, drug delivery vehicles, and supported synthesis. A robust, customizable method that allows modification of size, degree of cross-linking, identity of the crosslinker, and desired functionality, while retaining particle integrity would be highly advantageous. Here, we report the straightforward, versatile syntheses of cross-linked carboxy polystyrene (PS) particles ranging from 50 nm to 500 mu m in diameter that retain their morphology in organic solvents. Removal of a protecting group exposed free benzoic acid groups that were readily functionalized to afford peroxide, ester, or amide moieties. The identity and density of the crosslinker were also systematically modified to alter the swelling properties of the microparticles. The particles were rigorously characterized by IR and C-13 NMR spectroscopy, SEM, and optical imaging. The methods reported here provide a robust and reliable way to systematically and reproducibly synthesize functionalized cross linked PS-based particles spanning a wide range of sizes.
URI
http://pubs.kist.re.kr/handle/201004/68988
ISSN
0014-3057
Appears in Collections:
KIST Publication > Article
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