Size control of cross-linked carboxy-functionalized polystyrene particles: Four orders of magnitude of dimensional versatility
- Size control of cross-linked carboxy-functionalized polystyrene particles: Four orders of magnitude of dimensional versatility
- 강진구; Nina M. Sekerak; Kristin M. Hutchins; Binbin Luo; Paul V. Braun; Qian Chen; Jeffrey S. Moore
- Issue Date
- European polymer journal
- VOL 101-210
- Synthesis of functionalized organic particles is an expanding area of exploration due to versatile potential applications including imaging agents, drug delivery vehicles, and supported synthesis. A robust, customizable method that allows modification of size, degree of cross-linking, identity of the crosslinker, and desired functionality, while retaining particle integrity would be highly advantageous. Here, we report the straightforward, versatile syntheses of cross-linked carboxy polystyrene (PS) particles ranging from 50 nm to 500 mu m in diameter that retain their morphology in organic solvents. Removal of a protecting group exposed free benzoic acid groups that were readily functionalized to afford peroxide, ester, or amide moieties. The identity and density of the crosslinker were also systematically modified to alter the swelling properties of the microparticles. The particles were rigorously characterized by IR and C-13 NMR spectroscopy, SEM, and optical imaging. The methods reported here provide a robust and reliable way to systematically and reproducibly synthesize functionalized cross linked PS-based particles spanning a wide range of sizes.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.