Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Title
Proteogenomic Characterization of Human Early-Onset Gastric Cancer
Authors
양은경Kyu Sang SongDongmin ParkJun Won ParkHenry RodriguezJaesang KimHookeun LeeKwang Pyo KimHark Kyun KimEunok PaekSanghyuk LeeSang-Won LeeDaehee HwangDong-Gi MunJinhyuk BhinSangok KimHyunwoo KimJae Hun JungYeonjoo JungYe Eun JangJong Moon ParkHokeun KimYeonhwa JungHangyeore LeeJingi BaeSeunghoon BackSu-Jin KimJieun KimHeejin ParkHonglan LiKyu-Baek HwangYoung Soo ParkJeong Hwan YookByung Sik KimSun Young KwonSeung Wan RyuDo Youn ParkTae Yong JeonDae Hwan KimJae-Hyuck LeeSang-Uk Han
Issue Date
2019-01
Publisher
Cancer cell
Citation
VOL 35, NO 1-124
Abstract
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
URI
http://pubs.kist.re.kr/handle/201004/69055
ISSN
1535-6108
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KIST Publication > Article
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