Mechanistic/mammalian target of rapamycin: Recent pathological aspects and inhibitors

Title
Mechanistic/mammalian target of rapamycin: Recent pathological aspects and inhibitors
Authors
오창현사미르엘가말다리라아쉬라프모하메드
Keywords
anticancer; kinase inhibitors; mTOR; PI3K; aging
Issue Date
2019-02
Publisher
Medicinal research reviews
Citation
VOL 39, NO 2-664
Abstract
The mechanistic/mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, regulates many normal cell processes such as transcription, cell growth, and autophagy. Overstimulation of mTOR by its ligands, amino acids, sugars, and/or growth factors leads to physiological disorders, including cancer and neurodegenerative diseases. In this study, we reviewed the recent advances regarding the mechanism that involves mTOR in cancer, aging, and neurodegenerative diseases. The chemical and biological properties of recently reported small molecules that function as mTOR kinase inhibitors, including adenosine triphosphate‐ competitive inhibitors and dual mTOR/PI3K inhibitors, have also been reviewed. We focused on the reports published in the literature from 2012 to 2017.
URI
http://pubs.kist.re.kr/handle/201004/69056
ISSN
0198-6325
Appears in Collections:
KIST Publication > ETC
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