Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata
- Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata
- 권재영; Nguyen Tuan Hiep; Sungeun Hong; Nahyun Kim; Yuanqiang Guo; Bang Yeon Hwang; Woongchon Mar; Dongho Lee
- Issue Date
- Scientific Reports
- VOL 9, NO 1757-9
- Seven pairs of enantiomeric isoflavones (1a/1b– 7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral highpressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC50 values of 5.5 μM, 4.0 μM, and 10.0 μM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC50 values of 6.9 μM, 4.5 μM, and 9.5 μM, respectively.
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