Ascorbic Acid Mitigates D-galactose-Induced BrainAscorbic Acid Mitigates D-galactose-Induced Brain
- Ascorbic Acid Mitigates D-galactose-Induced BrainAscorbic Acid Mitigates D-galactose-Induced Brain
- 임혜원; 서미순; 남석민; 서진석; 남상섭; 조익현; 장병준; 김현중; 최선혜; 나승열
- Issue Date
- VOL 11, NO 1-176-17
- Ascorbic acid is essential for normal brain development and homeostasis. However, the effect
of ascorbic acid on adult brain aging has not been determined. Long-term treatment with high levels of D-galactose (D-gal) induces brain aging by accumulated oxidative stress. In the present study, mice were subcutaneously administered with D-gal (150 mg/kg/day) for 10 weeks; from the seventh week, ascorbic acid (150 mg/kg/day) was orally co-administered for four weeks. Although D-gal administration alone reduced hippocampal neurogenesis and cognitive functions, co-treatment of ascorbic acid with D-gal effectively prevented D-gal-induced reduced hippocampal neurogenesis through improved cellular proliferation, neuronal differentiation, and neuronal maturation. Long-term D-gal treatment also reduced expression levels of synaptic plasticity-related markers, i.e., synaptophysin and phosphorylated Ca2+/calmodulin-dependent protein kinase II, while ascorbic acid prevented the reduction in the hippocampus. Furthermore, ascorbic acid ameliorated D-gal-induced downregulation of superoxide dismutase 1 and 2, sirtuin1, caveolin-1, and brain-derived neurotrophic factor and upregulation of interleukin 1 beta and tumor necrosis factor alpha in the hippocampus. Ascorbic acid-mediated hippocampal restoration from D-gal-induced impairment was associated with an enhancedhippocampus-dependentmemory function. Therefore, ascorbic acidamelioratesD-gal-induced impairments through anti-oxidative and anti-inflammatory effects, and it could be an effective dietary
supplement against adult brain aging.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.