Ascorbic Acid Mitigates D-galactose-Induced BrainAscorbic Acid Mitigates D-galactose-Induced Brain

Title
Ascorbic Acid Mitigates D-galactose-Induced BrainAscorbic Acid Mitigates D-galactose-Induced Brain
Authors
임혜원서미순남석민서진석남상섭조익현장병준김현중최선혜나승열
Issue Date
2019-01
Publisher
Nutrients
Citation
VOL 11, NO 1-176-17
Abstract
Ascorbic acid is essential for normal brain development and homeostasis. However, the effect of ascorbic acid on adult brain aging has not been determined. Long-term treatment with high levels of D-galactose (D-gal) induces brain aging by accumulated oxidative stress. In the present study, mice were subcutaneously administered with D-gal (150 mg/kg/day) for 10 weeks; from the seventh week, ascorbic acid (150 mg/kg/day) was orally co-administered for four weeks. Although D-gal administration alone reduced hippocampal neurogenesis and cognitive functions, co-treatment of ascorbic acid with D-gal effectively prevented D-gal-induced reduced hippocampal neurogenesis through improved cellular proliferation, neuronal differentiation, and neuronal maturation. Long-term D-gal treatment also reduced expression levels of synaptic plasticity-related markers, i.e., synaptophysin and phosphorylated Ca2+/calmodulin-dependent protein kinase II, while ascorbic acid prevented the reduction in the hippocampus. Furthermore, ascorbic acid ameliorated D-gal-induced downregulation of superoxide dismutase 1 and 2, sirtuin1, caveolin-1, and brain-derived neurotrophic factor and upregulation of interleukin 1 beta and tumor necrosis factor alpha in the hippocampus. Ascorbic acid-mediated hippocampal restoration from D-gal-induced impairment was associated with an enhancedhippocampus-dependentmemory function. Therefore, ascorbic acidamelioratesD-gal-induced impairments through anti-oxidative and anti-inflammatory effects, and it could be an effective dietary supplement against adult brain aging.
URI
http://pubs.kist.re.kr/handle/201004/69062
ISSN
2072-6643
Appears in Collections:
KIST Publication > Article
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