Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function
- Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function
- 박미경; 손희성
- Palmitoylation; AMPA receptor; Synapse; Trafficking
- Issue Date
- Archives of pharmacal research
- VOL 42, NO 5-435
- The a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a major glutamate-gated ion channel in the brain and is important for synaptic transmission, synaptic plasticity, and learning. Palmitoylation, a post-translational modification, is a critical process regulatingAMPARtrafficking, synaptic function and plasticity, and learning and memory in health and diseases. In this review, we discuss current knowledge on the palmitoylation-dependent regulation of AMPAR trafficking and functions. We focus on the palmitoylation of AMPARs and other synaptic proteins that directly or indirectly interact with AMPARs, including postsynaptic density 95, glutamate receptor-interacting protein/AMPAR-binding protein, A-kinase anchoring protein 79/150, and protein interacting with C kinase 1. Finally, we discuss what future studies should address in the field of palmitoylation-dependent AMPAR trafficking and function with regard to physiology and neurodegenerative diseases.
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