Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function

Title
Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function
Authors
박미경손희성
Keywords
Palmitoylation; AMPA receptor; Synapse; Trafficking
Issue Date
2019-05
Publisher
Archives of pharmacal research
Citation
VOL 42, NO 5-435
Abstract
The a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is a major glutamate-gated ion channel in the brain and is important for synaptic transmission, synaptic plasticity, and learning. Palmitoylation, a post-translational modification, is a critical process regulatingAMPARtrafficking, synaptic function and plasticity, and learning and memory in health and diseases. In this review, we discuss current knowledge on the palmitoylation-dependent regulation of AMPAR trafficking and functions. We focus on the palmitoylation of AMPARs and other synaptic proteins that directly or indirectly interact with AMPARs, including postsynaptic density 95, glutamate receptor-interacting protein/AMPAR-binding protein, A-kinase anchoring protein 79/150, and protein interacting with C kinase 1. Finally, we discuss what future studies should address in the field of palmitoylation-dependent AMPAR trafficking and function with regard to physiology and neurodegenerative diseases.
URI
http://pubs.kist.re.kr/handle/201004/69137
ISSN
0253-6269
Appears in Collections:
KIST Publication > Article
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