Thieno[2,3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances

Title
Thieno[2,3-d] pyrimidine as a promising scaffold in medicinal chemistry: Recent advances
Authors
오창현Mohammed samir호스니 알리
Keywords
Thienopyrimidine; Anti-inflammatory; Anticancer; Antimicrobial; Antiviral; CNS protective agents
Issue Date
2019-04
Publisher
Bioorganic & medicinal chemistry
Citation
VOL 27, NO 7-1194
Abstract
Thienopyrimidine scaffold is a fused heterocyclic ring system that structurally can be considered as adenine, the purine base that is found in both DNA and RNA-bioisosteres. Thienopyrimidines exist in three distinct isomeric forms. The current review discusses thieno[2,3-d]pyrimidine as a one of the opulent heterocycles in drug discovery. Its broad range of medical applications such as anticancer, anti-inflammatory, anti-microbial, and CNS protective agents has inspired us to study its structure-activity relationship (SAR), along with its relevant synthetic strategies. The present review briefly summarizes synthetic approaches for the preparation of thieno[2,3-d]pyrimidine derivatives. In addition, the promising biological activities of this scaffold are also illustrated with explanatory diagrams for their SAR studies.
URI
http://pubs.kist.re.kr/handle/201004/69140
ISSN
0968-0896
Appears in Collections:
KIST Publication > ETC
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