Effects of channel aspect ratio on microfluidic-chip design of hydrodynamic filtration for particle sorting
- Effects of channel aspect ratio on microfluidic-chip design of hydrodynamic filtration for particle sorting
- 전명석; 전병진
- hydrodynamic filtration; particle sorting; microfluidic-chip; channel design; flow fraction; particle tracing
- Issue Date
- Journal of physics D, applied physics
- VOL 52, NO 22-9
- The model framework of hydrodynamic filtration was examined for the rational design of
particle sorting, by considering the complete analysis of 3D laminar flow for flow fraction
and complicated networks of main and multiple branch channels. As the objective parameters
for tuning of the design, both the number of branch channels and each length of individual
branches were decided for different aspect ratios (i.e. H/W = 0.5-2.5) of rectangular channel.
In order to validate our model framework, we compared the results estimated by analytical
model with those computed by numerical simulations. The number of branches and the their
individual lengths decrease distinctly with increasing channel aspect ratio, so that a channel
with deep geometry enables compact design of microfluidic-chip being operated by lower
pressure drop under the same throughput condition. Pursuing the justification of this behavior,
pressure drop, average fluid velocity, and the ratio of flow fraction at each branch point were
quantified with variations of aspect ratios.
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