Chemoenzymatic synthesis of spinosyn A

Title
Chemoenzymatic synthesis of spinosyn A
Authors
전병선Hak Joong KimSei-hyun ChoiNamho KimRongson PongdeeQingquan WuHung-wen Liu
Issue Date
2014-12
Publisher
Angewandte Chemie international edition
Citation
VOL 53, NO 49-13557
Abstract
Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used polyketide insecticide spinosyn A by exploiting the prowess of both chemical and enzymatic methods. As more polyketide biosynthetic pathways are characterized, this chemoenzymatic approach is expected to become readily adaptable to streamlining the synthesis of other complex polyketides with more elaborate post-PKS modifications.
URI
http://pubs.kist.re.kr/handle/201004/69176
ISSN
1433-7851
Appears in Collections:
KIST Publication > Article
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