Hemodynamic correlation imaging of the mouse brain for application in unilateral neurodegenerative diseases

Title
Hemodynamic correlation imaging of the mouse brain for application in unilateral neurodegenerative diseases
Authors
윤인찬송강일Seung-ho PaikSedef ErdoganZephaniah Phillips VYoung-Kyu KimSunghee ParkYoungwoon ChoiBeop-Min Kim
Keywords
Hemodynamic; Neurodegeneration
Issue Date
2019-04
Publisher
Biomedical optics express[electronic resource].
Citation
VOL 10, NO 4-1749
Abstract
We developed a single-camera two-channel hemodynamic imaging system that uses near-infrared light to monitor the mouse brain in vivo with an exposed, un-thinned, and intact skull to explore the effect of Parkinson’s disease on the resting state functional connectivity of the brain. To demonstrate our system’s ability to monitor cerebral hemodynamics, we first performed direct electrical stimulation of an anesthetized healthy mouse brain and detected hemodynamic changes localized to the stimulated area. Subsequently, we developed a unilaterally lesioned 6-hydroxydopamine (hemi-parkinsonian) mouse model and detected the differences in functional connectivity between the normal and hemi-parkinsonian mouse brains by comparing the hemispheric hemodynamic correlations during the resting state. Seed-based correlation for the oxy-hemoglobin channel from the left and right hemispheres of healthy mice was much higher and more symmetric than in hemi-parkinsonian mice. Through a k-means clustering of the hemodynamic signals, the healthy mouse brains were segmented according to brain region, but the hemi-parkinsonian mice did not show a similar segmentation. Overall, this study highlights the development of a spatial multiplexing hemodynamic imaging system that reveals the resting state hemodynamic connectivity in healthy and hemi-parkinsonian mice.
URI
http://pubs.kist.re.kr/handle/201004/69181
ISSN
2156-7085
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE