Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
- Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
- 홍석원; Su-Eon Jin; Jun Eon Jin; Woochul Hwang
- zinc oxide nanoparticles; immobilization; dual UV; antibacterial; disinfection; toxicity
- Issue Date
- International journal of nanomedicine
- VOL 14-1751
- Background: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use
in various applications such as gas sensors and semiconductors.
Aim: In this study, their antibacterial activity against Escherichia coli under dual ultraviolet
(UV) irradiation for disinfection was investigated.
Materials and methods: ZnO nanoparticles were synthesized and immobilized onto silicon
(Si) wafers by self-assembly. The physicochemical properties and antibacterial activity of ZnO
nanoparticles and their networks were evaluated. Gene ontology was analyzed and toxicity
levels were also monitored.
Results: Synthesized ZnO nanoparticles were spherical nanocrystals (,100 nm; Zn, 47%; O, 53%) that formed macro– mesoporous three-dimensional nanostructures on Si wafers in a
concentration-dependent manner. ZnO nanoparticles and their networks on Si wafers had an
excellent antibacterial activity against E. coli under dual UV irradiation (.3log CFU/mL).
Specifically, arrayed ZnO nanoparticle networks showed superior activity compared with free
synthesized ZnO nanoparticles. Oxidative stress-responsive proteins in E. coli were identified
and categorized, which indicated antibacterial activity. Synthesized ZnO nanoparticles were
less cytotoxic in HaCaT with an IC50 of 6.632 mg/mL, but phototoxic in Balb/c 3T3.
Conclusion: The results suggested that ZnO nanoparticles and their networks can be promising photocatalytic antibiotics for use in next-generation disinfection systems. Their application could also be extended to industrial and clinical use as effective and safe photocatalytic antibiotics.
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