Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells

Title
Cytotoxic Constituents from the Roots of Asarum sieboldii in Human Breast Cancer Cells
Authors
김수남김은애김현정곽아원강복윤조승식심정현윤구Ha-Na Oh
Keywords
Asarum sieboldii; cytotoxicity; breast cancer; xanthoxylol
Issue Date
2019-03
Publisher
Natural Product Sciences
Citation
VOL 25, NO 1-75
Abstract
Bioassay-guided fractionation of the roots of Asarum sieboldii led to the isolation of the six compounds methylkakuol (1), sesamin (2), asarinin (3), xanthoxylol (4), and (2E,4E,8Z,10E/Z)-N-(2-methylpropyl) dodeca-2,4,8,10-tetraenamide (5/6). Among the isolates, xanthoxylol (4) exhibited significant cytotoxicity against human breast cancer cells MCF-7 and MDA-MB-231 in vitro with IC50 values of 9.15 and 13.95 μM, respectively.
URI
http://pubs.kist.re.kr/handle/201004/69222
ISSN
1226-3907
Appears in Collections:
KIST Publication > Article
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