14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors

Title
14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors
Authors
황은미Do Eon KimChang-Hoon ChoKyoung Mi SimOsung KwonHyung-Wook KimJae-Yong Park
Issue Date
2019-02
Publisher
Experimental Neurobiology
Citation
VOL 28, NO 1-53
Abstract
14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.
URI
http://pubs.kist.re.kr/handle/201004/69223
ISSN
1226-2560
Appears in Collections:
KIST Publication > Article
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