Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.

Title
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
Authors
이욱빈강지선최원영장권일김철한최은영하정실김영준
Issue Date
2016-04
Publisher
Nature Communications
Citation
VOL 7, NO 11322
Abstract
In response to persistent mycobacteria infection, the host induces a granuloma, which often fails to eradicate bacteria and results in tissue damage. Diverse host receptors are required to control the formation and resolution of granuloma, but little is known concerning their regulatory interactions. Here we show that Mincle, the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production. In addition to its stimulatory role on TLR-mediated transcription, Mincle enhanced the translation of key genes required for nitric oxide synthesis through p38 and eIF5A hypusination, leading to granuloma resolution. Thus, Mincle has dual functions in the promotion and subsequent resolution of inflammation during anti-mycobacterial defence using both transcriptional and translational controls.
URI
http://pubs.kist.re.kr/handle/201004/69296
ISSN
2041-1723
Appears in Collections:
KIST Publication > Article
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