Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells.
- Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells.
- 이욱빈; Un Yung Choi; Ji Yeon Hur; Myeong Sup Lee; Quanri Zhang; Won Young Choi; Lark Kyun Kim; Goo Taeg Oh; Young-Joon Kim
- Issue Date
- PLoS ONE
- VOL 9, NO 4-e95805-11
- To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we generated Trim30 knockout (Trim30(-/-)) mice. Trim30 deletion caused no major developmental defects in any organs, nor showed any discernable defect in the activation of macrophages. But, Trim30(-/-) mice showed increased CD4/CD8 ratio when aged and Trim30(-/-) CD4(+) T cells exhibited an abnormal response upon TCR activation, in particular in the absence of a costimulatory signal. Adoptive transfer of wild-type and Trim30(-/-) CD4(+) T cells together into lymphopenic hosts confirmed higher proliferation of the Trim30(-/-) CD4(+) T cells in vivo. Despite the enhanced proliferation, Trim30(-/-) T cells showed decreased levels of NF-kappa B activation and IL-2 production compared to wild-type cells. These results indicate a distinct requirement for TRIM30 in modulation of NF-kappa B activation and cell proliferation induced by TCR stimulation.
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