Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats
- Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats
- 박영태; Sun Min Lee; Nayoung Kim; Ryoung Hee Nam; Ji Hyun Park; Soo In Choi; Yeon-Ran Kim; Yeong-Jae Seok; Cheol Min Shin; Dong Ho Lee
- Issue Date
- Scientific Reports
- VOL 9, NO 6626-11
- The association between adverse effects of PPI and gut microbiota in old age has yet to be
elucidated. We assessed changes in the gut microbiota and butyrate levels following the long-term administration of PPIs to old rats and investigated their associations. F344 aged male rats were fed a PPI-supplemented diet for 50 weeks. The ileal microbiota was analysed by metagenomic sequencing of the 16S rRNA, while the butyrate concentration was measured by high-performance liquid chromatography. We observed a significant decrease in microbial diversity following PPI administration in the 2-year-old rats but not in the 74-week-old rats. PPI treatment reduced both commensal bacteria and opportunistic pathogens, particularly in the 2-year-old rats. Enterotypes comprising the majority of the control samples were enriched in Lactobacillus, while other enterotypes in the PPI group were dominated by Turicibacter or Romboutsia. The PPI treatment reduced the butyrate concentrations in the intestines and colons of 74-week-old rats compared to the control group. The abundance of Lactobacillus significantly correlated with butyrate concentrations in 74-week-old rats. In conclusion, long-term administration of PPIs alters the gut microbiota and butyrate concentrations in rats, particularly in old age, which may be an underlying mechanism of PPI-induced adverse effects such as pseudomembranous colitis.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.