Crosstalk between Oxidative Stress and Tauopathy

Title
Crosstalk between Oxidative Stress and Tauopathy
Authors
이준석김윤경디라제 무라레마무눌 하크
Keywords
oxidative stress; tauopathy
Issue Date
2019-04
Publisher
International journal of molecular sciences
Citation
VOL 20, NO 8-1959-20
Abstract
Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors. Recently, reactive oxygen species (ROS) have attracted attention due to their upstream and downstream effects on tauopathy. In physiological conditions, healthy cells generate a moderate level of ROS for self-defense against foreign invaders. Imbalances between ROS and the anti-oxidation pathway cause an accumulation of excessive ROS. There is clear evidence that ROS directly promotes tau modifications in tauopathy. ROS is also highly upregulated in the patients' brain of tauopathies, and anti-oxidants are currently prescribed as potential therapeutic agents for tauopathy. Thus, there is a clear connection between oxidative stress (OS) and tauopathies that needs to be studied in more detail. In this review, we will describe the chemical nature of ROS and their roles in tauopathy.
URI
http://pubs.kist.re.kr/handle/201004/69327
ISSN
1422-0067
Appears in Collections:
KIST Publication > ETC
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