Antihyperlipidemic and antioxidative potentials of onion extract fermented with a novel lactobacillus casei HD-010

Title
Antihyperlipidemic and antioxidative potentials of onion extract fermented with a novel lactobacillus casei HD-010
Authors
김진철양웅석이재용김철호황철원
Keywords
Antihyperlipidemic; Antioxidative; Fermented onion; lactobacillus casei
Issue Date
2019-03
Publisher
Evidence-based Complementary and Alternative Medicine : eCAM
Citation
VOL 2019-10
Abstract
The purpose of this study was to investigate antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus casei HD-010. In general, fermented onion extract is used for its antioxidative activity (ORAC), inhibitory effect on adipocytes differentiation, quercetin contents, and antihyperlipidemic activities. However, the effect of fermented onion extract on hyperlipidemia after oral administration using ApoE-deficient mice has not been reported yet. To understand the effect of fermented onion extract on hyperlipidemia, we used benzafibrate (10 mg/kg, bw/day) as a positive control in the present study. Serum was collected every week to analyze levels of low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG), and cholesterol, 3-hydroxy-3-methylgutaryi-CoA (HMG-CoA) reductase activity, and cholesterol ester transport protein (CETP) activity. In the fermented onion-treated group, HDL level was significantly increased while levels of TG and LDL were significantly decreased compared to those in the control group. In addition, the inhibition activity of HMG-CoA reductase was increased 20% in the fermented onion-treated group at 100mg/kg.CETP activity has been observed to be significantly inhibited in the fermented onion-treated groups compared to that in the control group.These results suggest that fermented onion has a preventive/therapeutic effect on hyperlipidemic disease. It might have potential to be developed as a functional food.
URI
http://pubs.kist.re.kr/handle/201004/69348
ISSN
1741-427X
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KIST Publication > Article
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