Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

Title
Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.
Authors
김인산Seung-Yoon Park
Issue Date
2019-06
Publisher
Cancer letters
Citation
VOL 452-58
Abstract
Myeloid lineage immune cells, such as macrophages and dendritic cells, play important roles in the induction of antitumor immunity during the initial stage of the cancer-immunity cycle, eliciting antitumor adaptive immunity by phagocytosing cancer cells and processing cancer-specific antigens, and then presenting these antigens to T cells. During this process, cancer cell phagocytosis can be prevented by inhibitory signals, and the signaling cascades that elicit immune responses against cancer antigens can be inhibited by immunosuppressive myeloid cells in the tumor microenvironment. A number of therapeutic strategies for enhancing cancer cell phagocytosis and promoting antitumor immunity by targeting myeloid lineage cells have recently been developed. Here, we discuss recent advances in cancer immunotherapy that involve the targeting of myeloid lineage immune cells to induce effective antitumor immunity.
URI
http://pubs.kist.re.kr/handle/201004/69359
ISSN
0304-3835
Appears in Collections:
KIST Publication > ETC
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