Protease-activated drug development

Title
Protease-activated drug development
Authors
최기영Magdalena Swierczewska이슬기Xiaoyuan Chen
Issue Date
2012-02
Publisher
Theranostics
Citation
VOL 2, NO 2-178
Abstract
In this extensive review, we elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer. First, key proteases are introduced along with their function in disease progression. Next, we link these proteases as targets for the development of prodrugs and provide clinical examples of protease-activatable prodrugs. Finally, we provide significant design considerations needed for the development of the next generation protease-targeted and protease-activatable prodrugs.
URI
http://pubs.kist.re.kr/handle/201004/69376
ISSN
1838-7640
Appears in Collections:
KIST Publication > Article
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