A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications

Title
A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications
Authors
최기영Magdalena SwierczewskaEdward L. MertzXinglu HuangFan ZhangLei Zhu박재형Ashwinkumar Bhirde이슬기Xiaoyuan ChenHong Yeol Yoon
Issue Date
2012-07
Publisher
Nano letters
Citation
VOL 12, NO 7-3620
Abstract
Despite their immense potential in biomedicine, carbon nanomaterials suffer from inefficient dispersion and biological activity in vivo. Here we utilize a single, yet multifunctional, hyaluronic acid-based biosurfactant to simultaneously disperse nanocarbons and target single-walled carbon nanotubes (SWCNTs) to CD44 receptor positive tumor cells with prompt uptake. Cellular uptake was monitored by intracellular enzyme-activated fluorescence, and localization of SWCNTs within cells was further confirmed by Raman mapping. In vivo photoacoustic, fluorescence, and positron emission tomography imaging of coated SWCNTs display high tumor targeting capability while providing long-term, fluorescence molecular imaging of targeted enzyme events. By utilizing a single biomaterial surfactant for SWCNT dispersion without additional bioconjugation, we designed a facile technique that brings nanocarbons closer to their biomedical potential.
URI
http://pubs.kist.re.kr/handle/201004/69377
ISSN
1530-6984
Appears in Collections:
KIST Publication > Article
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