Effect of chain flexibility on cell adhesion: Semi-flexible model based analysis of cell adhesion to hydrogels

Title
Effect of chain flexibility on cell adhesion: Semi-flexible model based analysis of cell adhesion to hydrogels
Authors
김상헌박귀덕오승자정지홍이주영송보아Ramesh Subbiah최우혁
Issue Date
2019-02
Publisher
Scientific Reports
Citation
VOL 9, NO 1-2463-8
Abstract
Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer chain flexibility on cell adhesion to various hydrogel constructs of collagen and fibrin gels. Specifically, novel method of semi-flexible model-based analysis confirmed that chain flexibility mediated microstructure of the hydrogels is a critical factor for cell adhesion on their surfaces. The proposed analysis showed possibility of more accurate prediction of biocompatibility of hydrogels, and it should be considered as one of the important criteria for polymer design and selections for enhancing both biocompatibility and biofunctionality.
URI
http://pubs.kist.re.kr/handle/201004/69494
ISSN
2045-2322
Appears in Collections:
KIST Publication > Article
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