Recent Developments in Metal-Catalyzed Bio-orthogonal Reactions for Biomolecule Tagging

Title
Recent Developments in Metal-Catalyzed Bio-orthogonal Reactions for Biomolecule Tagging
Authors
이준석디라제 무라레장세영Anne Doyoung Kim
Keywords
biocatalysis; click chemistry
Issue Date
2019-06
Publisher
Chembiochem : a European journal of chemical biology
Citation
VOL 20, NO 12-1507
Abstract
With the rapid advances in single-molecule and live-cell imaging studies to investigate biological problems, the role of chemical probes to monitor reactions in a live cell has considerably increased. However, selective labeling of a target protein or a specific residue is highly challenging due to the high complexity of the biological system. In particular, biological macromolecules (such as proteins, DNA, or RNA) share many functional groups that potentially cross-react with exogenous chemical probes. Thus, there are high demands for perfect biocompatible reactions utilizing biologically unavailable chemistry. Metal-catalyzed reactions have been extensively investigated as synthetic methodology studies, including initial attempts in applying the chemistry in aqueous solutions in vitro or even in biological conditions. Herein, the latest developments and progress in metal-catalyzed bio-orthogonal reactions for biomolecule labeling are summarized.
URI
http://pubs.kist.re.kr/handle/201004/69515
ISSN
1439-4227
Appears in Collections:
KIST Publication > ETC
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